Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry
نویسندگان
چکیده
منابع مشابه
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متن کاملDevelopmental roles of the histone lysine demethylases.
Since the discovery of the first histone lysine demethylase in 2004, two protein families with numerous members have been identified that demethylate various histone lysine residues. Initial studies of the histone lysine demethylases focused on their in vitro enzymatic activity but, more recently, model organisms have been used to examine the roles of these enzymes in vivo. Here, we review rece...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2011
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057111416660